Transmucosal routes of drug delivery offer distinct advantages compared with oral administration for systemic drug delivery.
These advantages include the bypass of the „first pass effect“ and a very fast absorption. Through this delivery method potentially even highly potent biopharmaceuticals could be made available.

 

The following example of questions could be answered with our nasal-buccal-models:

• How can I develop the right mucoadhesive tablet or patch?
• How can I measure the API release and absorption from my new developed orodispersible tablets?
• Is my nasal spray well tolerated?
• Do the excipients or preservatives have an nasal irritation effect?
• Is my API systemically or only locally available?
• Do the excipients or preservatives have an influence on the absorption of the API?

Models	Assays
Buccal porcine tissue	permeability kinetics Influence of enhancer
Nasal porcine tissue (Ussing Chamber)	Permeability kinetics Influence of excipient / enhancer