The ZIM-Project “Optimed” (intraoral Device for Optimal Medication Delivery) is a German-Israeli research and development project. Peh-Med Ltd, Across Barriers, the Institut für Mikro-und Informationstechnik der Hahn-Schickard-Gesellschaft e.V. (HSG-IMIT), and the Neurodegenerative service of the Eberhard-Karl University Tübingen (EKUT) are the partners involved in the project.

Parkinson’s disease is an incurable degenerative disorder of the central nervous system, causing slowness of movement and difficulty with walking and gait. Parkinson’s disease is treated by taking tablets. In advanced case of the disease the blood drug level must be much more exactly adjusted. This is not very convenient by using tablets and alternative therapies are invasive and very expensive.

The partners will develop and test the intraoral drug delivery systems “Optimed” during the R & D project.

Optimed represents a non-invasive, economic Parkinson therapeutic system, similar to a dental brace. The system is composed of an osmotic pump that delivers continually the drug to the buccal mucosa without any electronic needs. This allows a precise and regular adjustment of the drug blood level.

For the optimization and the use of the osmotic pump an in-vitro pharmacokinetic model will be developed, useful additives will be identified and checked in vivo.

Duration of the project: 2 years

Partner are:

  • HSG-IMIT, Villingen-Schwenningen
  • Peh-Med Ltd, Israel
  • Universitätsklinikum, Tübingen