Pulmonal

Model of the Respiratory Tract

diffusion0bThe respiratory tract is currently considered as an alternative to gastrointestinal or dermal drug deliv-ery systems. Determination of drug permeability across the lung epithelial barrier generally speeds up the drug development process, and models are needed for this purpose.
Across Barriers has implemented reliable models for the upper airways as well as for the deep lung.

 
 

 

The Following questions can be answered with our models:

  • Is my compound low permeable or high permeable?
  • Does it show dose linearity?
  • Is the compound systemically or only locally available?
  • Are there drug-drug interactions?
  • Are active transport systems, e.g. P-gp or others, involved in the transport?
  • Does the compound show toxic effects?

Models

Assays

Primary porcine lung epithelial cells

  • Permeability kinetics
  • Efflux investigation (ab, ba)
  • P-glycoprotein inhibition

Calu-3

  • Permeability kinetics
  • Efflux investigation (ab, ba)
  • P-glycoprotein inhibition

Factsheet "In-vitro pulmonary models"