Blood-Brain Barrier Model
The blood-brain barrier (BBB) is an active interface between the circulation and the central nervous system (CNS) which restricts the free movement of different substances between the two compartments and plays a crucial role in the maintenance of the homeostasis of the CNS.
The control over drug passage across the complex barriers between the blood and the brain is a challenging goal in drug discovery.
For this need Across Barriers has established and standardized an in vitro model of the blood-brain-barrier which is based on cerebral capillary endothelial cells.
Following questions could be answered with Across Barriers’ Blood-Brain-Barrier models:
- Before conducting full toxicological studies, how can I investigate the permeation behavior of drugs and their metabolites?
- Which specific transport mechanisms are involved in the permeation of my new API
- Does the compound show toxic effects?
- How can I obtain predictive data for my computational theoretical model?
Models |
Assays |
Primary cell culture of porcine brain endothelial cells |
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