Gastrointestinal Absorption Model

The models were calibrated with the 19 substances recommended by the FDA.

Models

Assays

Caco-2

  • Permeability screening
  • Permeability kinetics
  • Efflux investigations (ab, ba)
  • Active transport (4°C)
  • P-glycoprotein inhibitions
  • Influence of excipient / enhancer
  • BCS classification

Excised porcine Cut

  • Permeability kinetics
  • Influence of enhancer
  • Investigation of different gut areas
  • Influence of the formulation