Dissemination

Ergebnisse, die im Rahmen des europäischen Forschungsprojekts Memtrans (Projekt Nr.: LHSB-CT-2006-518246) erzielt wurden, wurden bei verschiedenen Konferenzen, Meetings oder Symposien, usw. vorgestellt.

Folgende Poster wurden vorgestellt:

Across Barriers GmbH:

“Utilization of Sample Pooling Technique : Simultaneous Quantification of Multiple Substances”
HPLC 2009 – 34th International Symposium on High Performance Liquid Phase Separations and Related Techniques, June 28 – July 02, 2009, Dresden

“Comparison of MDCK cells transfected with the human MDR1 gene and the Caco-2 cell line as model of the human intestinal mucosa”
PharmSciFair, June 8-12, 2009, Nice

“Development and pre-validation of an in-vitro method for the prediction of drug-drug interactions and intestinal absorptions as a tool for drug candidate selection”
Bioperspectives, October 7-8, 2008, Hannover
FIP, August 29 – September 5, 2008, Basel
PBP, April 07-10, 2008, Barcelona

Universidad de Valencia:

“Prevalidation of in vitro models for prediction of secretion processes at intestinal level”
PharmSciFair, June 8-12, 2009, Nice

Folgende Paper wurden veröffentlicht:

  • Schwab R, Micsik T, Szokoloczi O, Schafer E, Tihanyi B, Tihanyi T, Kupcsulik P, Diofalvi K, Mersich T, Besznyak I Jr, Zarand A, Mihalik R, Sarkadi B, Keri G, Pap A, Jakab F, Kopper L, Petak I.: Functional evaluation of multidrug resistance transporter activity in surgical samples of solid tumors. Assay Drug Dev Technol. 5, 541-550 (2007).
  • Telbisz A, Muller M, Ozvegy-Laczka C, Homolya L, Szente L, Varadi A, Sarkadi B.: Membrane cholesterol selectively modulates the activity of the human ABCG2  multidrug transporter. Biochim Biophys Acta. 1768, 2698–2713 (2007)Jul 10; [Epub ahead of print]
  • Orbán TI, Seres L, Ozvegy-Laczka C, Elkind NB, Sarkadi B, Homolya L.: Combined localization and real-time functional studies using a GFP-tagged ABCG2 multidrug transporter. Biochem Biophys Res Commun. 367, 667-73. Epub 2008 Jan 7. (2008)
  • Szakács, G., Váradi, A, Özvegy-Laczka, C, and Sarkadi, B. : The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicology (ADME-Tox) Drug Discovery Today, 13, 379-93. Epub 2008 Feb 20.(2008)
  • Seres L, Cserepes J, Elkind NB, Töröcsik D, Nagy L, Sarkadi B, Homolya L.: Functional ABCG1 expression induces apoptosis in macrophages and other cell types. Biochim Biophys Acta. 1778, 2378-2387. (2008)
  • Ozvegy-Laczka C, Laczkó R, Hegedus C, Litman T, Várady G, Goda K, Hegedus T, Dokholyan NV, Sorrentino BP, Váradi A, Sarkadi B.: Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter. J Biol Chem. 283, 26059-26070. Epub 2008 Jul 21(2008)
  • Apáti A, Orbán TI, Varga N, Németh A, Schamberger A, Krizsik V, Erdélyi-Belle B, Homolya L, Várady G, Padányi R, Karászi E, Kemna EW, Német K, Sarkadi B. : High level functional expression of the ABCG2 multidrug transporter in undifferentiated human embryonic stem cells. Biochim Biophys Acta. 1778, 2700-2709, (2008) Epub Aug 20.
  • Hegedus C, Szakács, G., Homolya, L., Orbán, T.I., Telbisz, Á., Jani, M., and Sarkadi B,: Ins and outs of the ABCG2 multidrug transporter: an update of in vitro functional assays. Advanced Drug Delivery Reviews, 61, 47–56 e-pub Dec 24, 2008  (2009)
  • Hegedus, C, Özvegy-Laczka, C., Szakács, G., and  Sarkadi, B. : Interaction of anticancer protein kinase inhibitors with ABC multidrug transporters: substrates and/or inhibitors? Current Cancer Drug Targets, in press (2009)
  • Orbán, T,  Apáti, A., Németh, A., Varga, N., Krizsik, V., Schamberger, A., Szebényi, K., Erdei, Z., Várady, G., Karászi, E., Homolya, L., Német, K., Gócza, E., Miskey, C., Mayes, L., Ivics, Z., Izsvák, Z., and Sarkadi, B.:Applying a “double-feature” promoter to identify cardiomyocytes differentiated from  human embryonic stem cells following transposon-based gene delivery.Stem Cells,  2009 Feb 20; 27, 1077-1087, (2009)
  • Polgar O, Ediriwickrema LS, Robey RW, Sharma A, Hegde RS, Li Y, Xia D, Ward Y, Dean M, Ozvegy-Laczka C, Sarkadi B, Bates SE.: Arginine 383 is a crucial residue in ABCG2 biogenesis. Biochim Biophys Acta. 2009 May 3. [Epub ahead of print] (2009)
  • Hegedus, C., Özvegy-Laczka, C., Apáti, A., Magócsi, M., Német, K., Örfi, L., Kéri, G., Katona, M., Takáts, Z., Szakács, G., Sarkadi, B.: Interaction of the second generation Bcr-Abl inhibitors nilotinib, dasatinib and bosutinib with the MDR1 and ABCG2 multidrug transporters. Brit. J. Pharmacol. accepted (2009).
  • 132. Hou, Yue-xian; Li, Chang-Zhong; Palaniyandi, Kanagaraj; Magtibay, Paul; Homolya, Laszlo; Sarkadi, Balazs; Chang, Xiu-bao : Effects of putative catalytic base mutation E211Q on ABCG2-mediated methotrexate transport.Biochemistry (bi-2009-00675v.R2), accepted (2009)
  • Katona M, Kiss K, Angyal V, Kucsma N, Sarkadi B, Takáts Z, Szakács G. A mass spectrometry based functional assay for the quantitative assessment of ABC transporter activity. Rapid Commun Mass Spectrom. 23, 3372-3376. [Epub ahead of print] (2009)